Histamine Rich Foods
- Canned Foods
- Cheeses Ciders
- Fermented Beverages
- Fermented Foods
- Fish- Herring, Mackerel, Sardines, Tuna
- Jams and Preserves
- Meats- Processed Meats, Salami, Sauerkraut, Sausage,
- Sour Cream
- Yeast extract
- Soy Products
- Soy sauces and fermented soybean curd
- Fermented Meats
Foods that release histamine into the body include:
- Certain Nuts
These foods inhibit phenylsulphotransferase therefore the breakdown of vasoactive amines and serotonin Penecillin, OCP and theophylline decrease B6
Are some people more prone to excess histamine?
Studies have shown that histamine-intolerant individuals may have a deficiency of the enzyme, diamine oxidase, in the small intestinal mucosa, resulting in decreased breakdown, and increased absorption of histamine in the gastrointestinal tract. Diamine oxidase levels are known to be about 500-fold elevated in pregnancy.
Almost 100 drugs have been shown to inhibit diamine oxidase, including:
- Clauvulanic acid found in Augmentin (antibiotics)
- Isoniazid (antibiotics used to treat tuberculosis)
- Metoclopropramide (used to treat 'stomach upsets')
- Verapamil (used to treat heart conditions)
- Monoamine oxidase inhibitors (older drugs used to treat depression)
- Herbal & Nutritional supplements are an area for future research.
Vitamin and Mineral supplements
Responses to vitamin and mineral supplements can be highly idiosyncratic. Most importantly, nutritional supplementation always works better in cases of deficiency. In relation to supplemet use, the jury is out due to limited scientific research. In orthomolecular therapy however, where this information comes from, patients blood levels are tested before and after treatment.
The bottom line is don't self prescribe megadoses of supplements as they can be dangerous and prolonged use can cause deficiencies by antagonising other nutrients. As I am a herbalist I predominantly use herbal medicine to lower histamine combined with B6 as it is a precurser to diamine oxidase the enzyme the lowers histamine. Please see also Carahelath Allergy. In relation to high histamine again I would prefer to use herbal medicine. Please see also Carahealth Heavy Metal Detox and diet to lower copper.
Histadelia (High Histamine)
Histadelia is a condition hypothesised by Carl Pfeiffer to involve elevated serum levels of histamine and basophils, which he says can be treated with methionine and vitamin B6 megadoses. Pfeiffer claims that "histadelia" can cause depression with or without psychosis, but no published clinical trials have tested the effectiveness of this therapy. Copper levels may be low to normal in patients with histadelia.
Histapenia (Low Histamine)
Histapenia in orthomolecular medicine is the condition of high serum copper with low histamine. Copper is part of the enzyme histaminase, which is involved in the metabolism of histamine. The ratio of copper to zinc is clinically more than the concentration of either of these trace metals. important The treatment programmes in orthomolecular therapy consist of the administration of zinc, manganese, vitamin C, niacin, vitamin B12, and folic acid to lower histamine. These minerals antagonise copper and therefore result in raising histamine. With this treatment the high blood copper is slowly reduced and histamine levles are raised.
Some studies suggest that Zinc, manganese, Niacin, Vitamin B12 and folic acid increase histamine levels.
Zinc appears to be does dependant. Low dose zinc or prolonged zinc can raise histamine levels . In contrast high doses of zinc can lower serum histadine and histamine due to its antagonistic effect on copper. Zinc also raises brain histamine, since Copper tends to lower it.
Eric R. Braverman et al., The healing nutrients within: facts, findings, and new research on amino acids.
G Marone, et al., Physiological concentrations of zinc inhibit the release of histamine from human basophils and lung mast cells. Biological Sciences Volume: 18, Issue: 1-2, Pages: 103-106.
Niacin definately raises histamine.
Kushnir-Sukhov NM, et al., Human mast cells are capable of serotonin synthesis and release. J Allergy Clin Immunol 119: 498-499, 2007.
Vitamin B12 supplementation improved histamine thresholds (reduced hyperresponsiveness) in vitamin-deficient patients without significantly changing them in control subjects.
Jacquelyn K. Beals, PhD.,Vitamin B12 Deficiency Implicated in Chronic Unexplained Cough. Medscape Medical News.
Alcohol is also seen as a histamine liberator, i.e., it can enhance the effect of histamine in sensitive individuals. B6 assists Diamine oxidase (DAO), an enzyme synthesised primarily in the gastrointestinal mucosal cells.
Carina is available to lecture for your group or institution on this subject
Carina Harkin BHSc.Nat.BHSc.Hom.BHSc.Acu. is a practitioner of 10 years, complementary medicine lecturer of 4 years and mother of six in Galway, Ireland who practices what she teaches.
For an appointment call Carina directly on 083 34 66 333.
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