Naturopathy, Acupuncture, Homeopathy, Nutrition, Herbal Medicine , Fluoride Removal Water Filters

Online Naturopathic Health Resource

This store is powered by Ecwid - E-Commerce Software. If your browser does not support JavaScript, please proceed to its simple HTML version.

Vitamin D and cancer: a review of molecular mechanisms.

The population-based association between low vitamin D status and increased cancer risk can be inconsistent, but it is now generally accepted. These relationships link low serum 25OHD (25-hydroxyvitamin D) levels to cancer, whereas cell-based studies show that the metabolite 1,25(OH)2D (1,25-dihydroxyvitamin D) is a biologically active metabolite that works through vitamin D receptor to regulate gene transcription.In the present review we discuss the literature relevant to the molecular events that may account for the beneficial impact of vitamin D on cancer prevention or treatment.

See also Naturopathic Causes and Treatment of Cancer

These data show that although vitamin D-induced growth arrest and apoptosis of tumour cells or their non-neoplastic progenitors are plausible mechanisms, other chemoprotective mechanisms are also worthy of consideration. These alternative mechanisms include enhancing DNA repair, antioxidant protection and immunomodulation. In addition, other cell targets, such as the stromal cells, endothelial cells and cells of the immune system, may be regulated by 1,25(OH)2D and contribute to vitamin D-mediated cancer prevention.

Fleet JC, Desmet M, Johnson R, Li Y. Vitamin D and cancer: a review of molecular mechanisms. Biochem J. 2012 Jan 1;441(1):61-76.

FacebookMySpaceTwitterGoogle BookmarksNewsvineLinkedinRSS FeedPinterest
English French German Italian Portuguese Russian Spanish
05594802
TodayToday1427
YesterdayYesterday3014
This_WeekThis_Week1427
This_MonthThis_Month82070